Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening.
Journal
European journal of cancer (Oxford, England : 1990)
Journal Volume
218
Start Page
Article number 115264
ISSN
1879-0852
Date Issued
2025-03-11
Author(s)
Mulshine, James L
Pyenson, Bruce
Healton, Cheryl
Aldige, Carolyn
Avila, Riccardo S
Blum, Torsten
Cham, Matthew
de Koning, Harry J
Fain, Sean B
Field, John K
Flores, Raja
Giger, Maryellen L
Gipp, Ilya
Grannis, Frederic W
Gratama, Jan Willem C
Kazerooni, Ella A
Kelly, Karen
Lancaster, Harriet L
Montuenga, Luis
Myers, Kyle J
Naghavi, Morteza
Osarogiagbon, Raymond
Pastorino, Ugo
Reeves, Anthony P
Rizzo, Albert
Ross, Sheila
Schneider, Victoria
Seijo, Luis M
Shaham, Dorith
Silva, Mario
Smith, Robert
Taioli, Emanuela
Ten Haaf, Kevin
van der Aalst, Carlijn M
Viola, Lucia
Vogel-Claussen, Jens
Walstra, Anna N H
Wu, Ning
Yip, Rowena
Yankelevitz, David F
Henschke, Claudia I
Oudkerk, Matthijs
Abstract
Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening's benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.
Subjects
Chest CT scan
Chronic obstructive pulmonary disease
Coronary artery disease
Emphysema
Lung cancer
Lung cancer screening
Quantitative imaging
SDGs
Type
review article