Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants from 29 Prospective Studies
Journal
Stroke
Journal Volume
55
Journal Issue
1
Pages
50-58
Date Issued
2024
Author(s)
O'Keefe J.H.
Tintle N.L.
Harris W.S.
O'Keefe E.L.
Sala-Vila A.
Attia J.
Garg G.M.
Hure A.
Bork C.S.
Schmidt E.B.
Venø S.K.
Chen, Yun-Yu (amelia)
Egert S.
Feldreich T.R.
Arnlov J.
Lind L.
Forouhi N.G.
Geleijnse J.M.
Pertiwi K.
Imamura F.
De Mello Laaksonen V.
Uusitupa W.M.
Tuomilehto J.
Laakso M.
Lankinen M.A.
Laurin D.
Carmichael P.-H.
Lindsay J.
Leander K.
Laguzzi F.
Swenson B.R.
Longstreth W.T.
Manson J.E.
Mora S.
Cook N.R.
Marklund M.
Melo Van Lent D.
Murphy R.
Gudnason V.
Ninomiya T.
Hirakawa Y.
Qian F.
Sun Q.
Hu F.
Ardisson Korat A.V.
Risérus U.
Lázaro I.
Samieri C.
Le Goff M.
Helmer C.
Steur M.
Voortman T.
Ikram M.K.
Tanaka T.
Das J.K.
Ferrucci L.
Bandinelli S.
Tsai M.
Guan W.
Garg P.
Verschuren W.M.M.
Boer J.M.A.
Biokstra A.
Virtanen J.
Wagner M.
Westra J.
Albuisson L.
Yamagishi K.
Siscovick D.S.
Lemaitre R.N.
Mozaffarian D.
Abstract
BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: =0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
Publisher
Wolters Kluwer Health
Type
journal article