Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields
Journal
Journal of Applied Physics
Journal Volume
113
Journal Issue
4
Date Issued
2013
Author(s)
Yang, H.C.
Chiu, L.L.
Liao, S.H.
Chen, H.H.
Horng, H.E.
Liu, C.W.
Liu, C.I.
Chen, K.L.
Chen, M.J.
Abstract
In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons’ spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.
SDGs
Type
journal article