Association between N Acetyltransferase 2 (Nat2) Genetic Polymorphism and Development of Breast Cancer in Post-Menopausal Chinese Women in Taiwan
Resource
INTERNATIONAL JOURNAL OF CANCER v.82 n.2 pp.175-179
Journal
INTERNATIONAL JOURNAL OF CANCER
Journal Volume
v.82
Journal Issue
n.2
Pages
175-179
Date Issued
1999
Date
1999
Author(s)
HUANG, CHIUN-SHENG
Abstract
The incidence of breast cancer has increased greatly in Taiwan over the past 2 decades. Increased exposure to environmental carcinogens, including aryl aromatic amines, as a result of the economic boom, is suspected to be one factor contributing to this increase. The enzyme N- acetyltransferase 2 (NAT2) determines the rate of metabolism of aryl aromatic amines, and therefore the NAT2 slow acetylator genotype is associated with an increased risk of cancer. Our present case-control study of 150 breast cancer patients and 150 healthy controls in Taiwan was performed to explore the association between NAT2 genetic polymorphism and individual susceptibility to breast cancer. A structured questionnaire was used to collect relevant information regarding all known or suspected risk factors of breast cancer. The NAT2 genotype was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) assay in 139 cases and 133 controls, and 28.8% and 21.1%, respectively, were found to have sl
Subjects
CIGARETTE-SMOKING
ACETYLATION POLYMORPHISM
COLORECTAL-CANCER
ALLELIC LOSS
RISK
PHENOTYPE
SDGs
Type
journal article