Real-World Data Validation of NAPOLI-1 Nomogram for the Prediction of Overall Survival in Metastatic Pancreatic Cancer
Journal
Cancers
Journal Volume
15
Journal Issue
4
Date Issued
2023-02-05
Author(s)
Su, Yung-Yeh
Chiang, Nai-Jung
Yang, Yi-Hsin
Yen, Chia-Jui
Bai, Li-Yuan
Chiu, Chang-Fang
Chuang, Shih-Chang
Chou, Wen-Chi
Chen, Jen-Shi
Chiu, Tai-Jan
Chen, Yen-Yang
Chan, De-Chuan
Peng, Cheng-Ming
Chiu, Sz-Chi
Li, Chung-Pin
Shan, Yan-Shen
Chen, Li-Tzong
Abstract
The nomogram derived from the pivotal phase III NAPOLI-1 study demonstrated a significant ability to predict median overall survival (OS) in gemcitabine-refractory metastatic pancreatic ductal adenocarcinoma (PDAC) treated with liposomal irinotecan plus fluorouracil and leucovorin (nal-IRI+5-FU/LV). However, the NAPOLI-1 nomogram has not been validated in a real-world setting and therefore the applicability of the NAPOLI-1 nomogram in daily practice remains unknown. This study aims to evaluate the NAPOLI-1 nomogram in a multicenter real-world cohort.
Subjects
nal-IRI; nomogram; pancreatic cancer; real-world
SDGs
Publisher
MDPI
Type
journal article