Endothelial cells adhesion and growth on PU sur faces with grafted RGDs piptides and blood compatibility of the enothelialized sur faces: Response to shear stress

We tested blood compatibility on the
modified polyurethane (PU) surface in static
and dynamic flow conditions. We had been
succeeding to graft glycol-Gly-Arg-Gly-Asp
(GRGD) peptide on the PU surface by photochemical
reaction. To characterize the PUPEG-
GRGD, ATR-FTIR and ESCA analysis
were applied to confirm this result. ESCA
analysis showed that the surface of PU-PEGGRGD
increased the its component of N1s
atom. In addition, PU-PEG-GRGD surface
showed the adsorption peak on FTIR
absorption analysis, which might indicate
GRGD peptide being grafted. We did grafted
different concentration of GRGD to PU-PEG
surfaces, and found that the surfaces can
facilitate endothelia cell adhesion and growth
with the increasing of the concentration of
GRGD.