Serum eosinophil cationic protein level and disease activity in chilhood rhinitis
Journal
Asian Pacific Journal of Allergy and Immunology
Journal Volume
22
Journal Issue
1
Pages
19-24
Date Issued
2004
Author(s)
Abstract
In order to investigate clinical markers of disease activity in childhood rhinitis, we compared various laboratory parameters to symptom scores of children with allergic rhinitis and non-allergic rhinitis. We measured the levels of serum total IgE, aeroallergen specific IgE, serum eosinophil cationic protein (ECP), and blood eosinophil counts in 71 children with allergic rhinitis and in 62 children with non-allergic rhinitis. We found a statistically significant difference in peripheral blood eosinophil counts between the allergic rhinitis and non-allergic rhinitis groups. Serum ECP levels were positively related to symptom scores in both groups. Peripheral blood eosinophil counts correlated with symptom scores only in the group with non-allergic rhinitis. The results demonstrated that serum ECP levels are of value in assessing disease activity in both allergic and non-allergic rhinitis, and peripheral blood eosinophil counts may play a role in the evaluation of symptom severity in non-allergic rhinitis.
SDGs
Other Subjects
eosinophil cationic protein; immunoglobulin E; adolescent; adult; allergic rhinitis; article; child; childhood disease; controlled study; correlation analysis; disease activity; disease marker; disease severity; eosinophil; female; human; human cell; immunoglobulin blood level; laboratory test; leukocyte count; major clinical study; male; protein blood level; rhinitis; scoring system; statistical analysis; symptomatology; Adolescent; Child; Child, Preschool; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Immunoglobulin E; Male; Prospective Studies; Rhinitis; Severity of Illness Index
Type
journal article