Association between Pertussis Cases and Pertussis Vaccination
Date Issued
2012
Date
2012
Author(s)
Wang, Chih-Ming
Abstract
Objectives: The pertussis epidemic occurred in recent years in Taiwan shows that although some children have been vaccinated more than three doses of pertussis vaccine, they still suffer from Bordetella pertussis infection. Thus, the aims of this study were to investigate the association between the pertussis cases and pertussis vaccination, and explore the relationship between the hospitalization of pertussis cases and pertussis vaccination by the data of infectious diseases from Centers for Disease Control, Taiwan.
Methods: In order to investigate the association between the pertussis vaccination and pertussis epidemic, data from January 2003 to April 2012 were used to calculate the ratio of different doses of pertussis vaccines and to analyze the association between pertussis-unvaccinated and pertussis infection. In addition, to explore the relationship between the hospitalization and pertussis-unvaccinated, data from 2010 to 2011 were used to calculate the ratio of clinical symptoms, hospitalization, the days of important symptoms and hospitalization, as well as analyze the association between hospitalization and pertussis-unvaccinated.
Results: The highest ratio of cases was the citizen whose age is beyond the vaccine protection (43.8%), followed by those below vaccination age (21.3%) and those completed four doses of pertussis vaccines (12.4%). The chi-square test demonstrates the association between "incompletely taking the four doses of pertussis vaccines" and "pertussis infection." In addition, the highest ratio of symptoms was cough (97.8%), followed by paroxysms of coughing (64.5%), and 47.1% people were hospitalized. The longest days of important symptom is cough (172 days), followed by cold-like symptoms (148 days), paroxysms of coughing (132 days), headache (102 days), and post-tussive vomiting (98 days after ). The top three number of average days were cough (22.8 days), cold-like (20.4 days), and paroxysms of coughing (19.8 days). The maximum days in the hospital were 20 days, and the minimum were 3 days, with an average of 8.4 days. The chi-square test demonstrates there is an association between " incompletely taking the four doses of pertussis vaccines" and "hospitalization."
Conclusion: This study found that the citizen whose age is beyond the vaccine protection may transmit the pertussis bacteria to the infants and young children not yet vaccinated. Therefore, the immune memory of older population should be waken up by the additional vaccination in order to avoiding transmit the pertussis bacteria to the surrounding high-risk groups of infants and young children. In addition, this study found that although the issue of infection after vaccination happen occasionally, the vaccination can still be effective in preventing pertussis. Even the infection risk still exists after vaccination; the vaccine may help people to reduce the probability of hospitalization.
Subjects
Pertussis
Whooping cough
Infections
Vaccine
SDGs
Type
thesis
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