Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction
Resource
APPLIED PHYSICS LETTERS,90(7),074105-0074105.
Journal
Applied Physics Letters
Pages
74105
Date Issued
2007-02
Date
2007-02
Author(s)
Hong, Chin-Yih
Chen, W. S.
Jian, Z. F.
Yang, S. Y.
Horng, H. E.
Yang, L. C.
Yang, H. C.
Abstract
In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility χac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for χac-reduction immunomagnetic detection.
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