Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer
Journal
European Journal of Cancer
Journal Volume
43
Journal Issue
8
Pages
1276-1282
Date Issued
2007
Author(s)
Lin J.-T.
Huang S.-P.
Lin Y.-B.
Abstract
The aim of this study was to determine the clinicopathological features of sporadic colon cancers with loss of imprinting (LOI) of insulin-like growth factor II (IGF-II) in Chinese patients. DNA from peripheral blood leucocytes and RNA from tumours were amplified and then digested with ApaI to determine the LOI status. Of the 316 patients enrolled for analysis, 149 were informative for IGF-II LOI. The positive rate of IGF-II LOI of colon cancer tissue was 47% (70/149) in Chinese patients. Proximal colon (64%) cancers were more likely to have LOI of IGF-II in tumour than distal colon (40.9%) cancers (odds ratio (OR) = 2.60, 95% confidence intervals (CI) = 1.21-5.56, p = 0.014). LOI of IGF-II in tumours was also associated with more advanced diseases (OR = 2.90, 95% CI = 1.05-8.04, p = 0.04). IGF-II LOI is present in high frequency in Chinese colon cancer patients, especially those with proximal cancer. ? 2007 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
DNA; RNA; somatomedin B; adult; advanced cancer; aged; article; ascending colon; cancer risk; cancer tissue; Chinese; clinical feature; colon cancer; confidence interval; controlled study; descending colon; female; gene amplification; genome imprinting; human; human tissue; leukocyte; major clinical study; male; priority journal; risk assessment; Aged; Colonic Neoplasms; Electrophoresis; Female; Genomic Imprinting; Humans; Insulin-Like Growth Factor Binding Protein 2; Male; Microsatellite Repeats; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors
Type
journal article