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Sex-moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Journal Volume
49
Journal Issue
8
Pages
1128
End Page
1138
Date Issued
2019-08
Author(s)
Chen, Chien-Han
Wu, Ming-Hsun
Chen, Pao-Jen
Wei, Tien-Shan
Tseng , Ching-Ing
Abstract
Elevated cord blood IgE (cIgE), a predictor of atopic diseases, is influenced by genetic and environmental factors. However, gene-environment interactions on cIgE elevation and their difference by sex remain largely unexplored.
Subjects
IgE; cord blood; prenatal environment; sex; single nucleotide polymorphism
SDGs
Other Subjects
DNA; immunoglobulin E; interleukin 13; interleukin 4; STAT6 protein; tobacco smoke; water; IL4 protein, human; immunoglobulin E; interleukin 13; interleukin 4; STAT6 protein; STAT6 protein, human; adult; Article; cohort analysis; controlled study; female; genetic variability; genotype; genotype environment interaction; household; human; immunoglobulin blood level; major clinical study; male; mold; newborn; odor; prenatal exposure; priority journal; prospective study; sex; single nucleotide polymorphism; structured questionnaire; third trimester pregnancy; umbilical cord blood; fetus blood; genetics; hypersensitivity; immunology; passive smoking; pregnancy; questionnaire; sexual characteristics; single nucleotide polymorphism; Female; Fetal Blood; Humans; Hypersensitivity; Immunoglobulin E; Infant, Newborn; Interleukin-13; Interleukin-4; Male; Polymorphism, Single Nucleotide; Pregnancy; Prenatal Exposure Delayed Effects; Sex Characteristics; STAT6 Transcription Factor; Surveys and Questionnaires; Tobacco Smoke Pollution
Publisher
WILEY
Type
journal article