A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
Journal
BMC ophthalmology
Journal Volume
22
Journal Issue
1
Date Issued
2022-02-22
Author(s)
Abstract
Pigment epithelial-derived factor (PEDF), a 50 kDa secreted glycoprotein, exhibits distinct effects on a range of cell types. PEDF has been shown to inhibit vascular endothelial growth factor (VEGF)-mediated angiogenesis and widely accepted as a promising agent for treatment eye diseases related to neovascularization. A pool of short peptide fragments derived from PEDF reportedly manifests angioinhibitory activity. This study aims to determine the minimal PEDF fragment which can exert the anti-VEGF effect.
Subjects
Apoptosis; Corneal neovascularization; Peptide; Pigment epithelial-derived factor; Vascular endothelial growth factor
SDGs
Type
journal article