Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy
Journal
American Journal of Neuroradiology
Journal Volume
29
Journal Issue
9
Pages
1644-1648
Date Issued
2008
Author(s)
Juan, C.-J.
Tsai, S.-Y.
Wang, C.-Y.
Chan, C.-C.
Huang, G.-S.
Chou, M.-C.
Lee, C.-S.
Ko, C.-W.
Cho, N.-Y.
Chen, Cheng-Yu
Abstract
The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved (1)H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.
Type
journal article