Evaluation of parametric and nonparametric two one-sided tests procedures for assessing bioequivalence of average bioavailability
Resource
Journal of Biopharmaceutical Statistics,3(1),85-102.
Journal
Journal of Biopharmaceutical Statistics
Journal Volume
3
Journal Issue
1
Pages
85-102
Date Issued
1993-01
Date
1993-01
Author(s)
Liu, J.P.
Abstract
A simulation study was conducted to compare the levels of significance and power between Schuirmann's and nonparametric two one-sided tests procedures for a 2 x 2 crossover design under different combinations of sample sizes, intrasubject variabilities, and underlying distributions. Empirical results suggest that Schuirmann's two one-sided tests procedure is robust to minor departure from the assumption of normality.
Type
journal article