Paeonol Derivative, 6′-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer’s Disease Mice Model
Journal
ACS Chemical Neuroscience
Series/Report No.
ACS Chemical Neuroscience
Journal Volume
15
Journal Issue
4
Start Page
724
End Page
734
ISSN
1948-7193
1948-7193
Date Issued
2024-02-21
Author(s)
Chen P.J.
Chien, Po-Chung
Tsai, Han-Jung
Chen, Yi-Ru
Chuang, Jen-Hua
Chou, Pei-Li
Lee, Guan-Chiun
Lin, Wenwei
Lin, Yenshou
DOI
10.1021/acschemneuro.3c00633
Abstract
; this compound is able to ameliorate the abnormal depolarization induced by Aβ42 oligomers. Our aim was to further find effective paeonol derivatives since paeonol has been previously studied. 6'-Methyl paeonol, one of the six paeonol derivatives surveyed, is able to inhibit the abnormal depolarization induced by Aβ oligomers. Furthermore, 6'-methyl paeonol is able to alleviate the NMDA- and AMPA-induced depolarization. When a molecular mechanism was investigated, 6'-methyl paeonol was found to reverse the Aβ-induced increase in ERK phosphorylation. At the animal level, mice injected with 6'-methyl paeonol showed little change in their basic physical parameters compared to the control mice. 6'-Methyl paeonol was able to ameliorate the impairment of memory and learning behavior in J20 mice, an AD mouse model, as measured by the Morris water maze. Thus, paeonol derivatives could provide a structural foundation for developing and designing an effective compound with promising clinical benefits.
SDGs
Publisher
American Chemical Society (ACS)
Type
journal article