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不同藥物對粒線體功能異常時鼠大腦病變的影響: 磁共振影像,質譜與組織變化的相關
Date Issued
1999
Date
1999
Author(s)
李旺祚
DOI
882314B002180
Abstract
Magnetic resonance imaging and in vivo proton
magnetic resonance spectroscopy were used to
evaluate the therapeutic effect of lamotrigine and MK-
801 on rat brain lesions induced by 3-nitropropionic
acid. Systemic administration of 3-nitropropionic acid
(15mg/kg/day) to two-month-old Sprague-Dawley rats
(n=10 for each group) for five consecutive days
induced selective striatal and hippocampal lesions and
specific behavioral change. Pretreatment with
lamotrigine (10mg/kg or 20mg/kg/day) or MK-801
(2mg/kg/day) attenuated the lesions and behavioral
change. There were no significant differences in T2
values of the striatum and hippocampus among rats
pretreated with MK-801, lamotrigine (20mg/kg) and
sham controls. Significant elevations of
succinate/creatine and lactate/creatine ratios and
decreases of N-acetylaspartate/creatine and
choline/creatine ratios were observed after 3-
nitropropionic acid injections (P<0.001). The changes
were nearly prevented after pretreatment with
lamotrigine (20mg/kg). However, the Nacetylaspartate/
creatine in rats pretreated with
lamotrigine (10mg/kg) (P<0.01) and MK-801 (P<0.05)
still showed significant reduction as compared with
sham controls. We conclude that both lamotrigine and
MK-801 are effective in attenuation of brain lesions
induced by 3-nitropropionic acid. A higher dose of
lamotrigine provides better neuroprotective effect than
MK-801. With better therapeutic effect and fewer side
effects, lamotrigine is more promising for the potential
clinical application.
magnetic resonance spectroscopy were used to
evaluate the therapeutic effect of lamotrigine and MK-
801 on rat brain lesions induced by 3-nitropropionic
acid. Systemic administration of 3-nitropropionic acid
(15mg/kg/day) to two-month-old Sprague-Dawley rats
(n=10 for each group) for five consecutive days
induced selective striatal and hippocampal lesions and
specific behavioral change. Pretreatment with
lamotrigine (10mg/kg or 20mg/kg/day) or MK-801
(2mg/kg/day) attenuated the lesions and behavioral
change. There were no significant differences in T2
values of the striatum and hippocampus among rats
pretreated with MK-801, lamotrigine (20mg/kg) and
sham controls. Significant elevations of
succinate/creatine and lactate/creatine ratios and
decreases of N-acetylaspartate/creatine and
choline/creatine ratios were observed after 3-
nitropropionic acid injections (P<0.001). The changes
were nearly prevented after pretreatment with
lamotrigine (20mg/kg). However, the Nacetylaspartate/
creatine in rats pretreated with
lamotrigine (10mg/kg) (P<0.01) and MK-801 (P<0.05)
still showed significant reduction as compared with
sham controls. We conclude that both lamotrigine and
MK-801 are effective in attenuation of brain lesions
induced by 3-nitropropionic acid. A higher dose of
lamotrigine provides better neuroprotective effect than
MK-801. With better therapeutic effect and fewer side
effects, lamotrigine is more promising for the potential
clinical application.
Subjects
3-nitropropionic acid
T2 maps
magnetic
resonance spectroscopy
resonance spectroscopy
N-acetylaspartate (NAA)
Publisher
臺北市:國立臺灣大學醫學院小兒科
Coverage
計畫年度:88;起迄日期:1998-08-01/1999-07-31
Type
report
File(s)
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Format
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