非小細胞肺癌之微衛星體複製突變與核酸修補基因 (HMSH2基因及HOGG1基因) 發生基因變異之相關聯性(I)
Other Title
Microsatellite Instability and Genetic Alteratin of Two DNA Repair Genes–hMSH2 Gene and hOGG1 Gene in Non-Small Cell Lung Cancer
Date Issued
1999
Date
1999
Author(s)
余忠仁
DOI
882314B002208
Abstract
Mutation accumulates throughout life
and is the underlying cause of cancer.
Recently, much attention has been paid to the
important role of the DNA mismatch repair
system in controlling the accumulation of
somatic mutations in human tissues and the
association of mismatch repair deficiency
with carcinogenesis. Microsatellite instability,
representing mutations of short repetitive
DNA sequence distributed within genomes,
appears to be a novel mechanism in
carcinogenesis and is thought to reflect
multiple replication errors from MMR genes.
Frequent (33-66%) presence of replication
error phenomenon in lung cancer have been
reported. There were significant differences
exists in the frequency of alterations in
individual marker, and data regarding the
alteration of MMR genes in lung cancer are
lacking. We propose a two-year study to
evaluate the frequency of microsatellite
instability in non-small cell lung cancer, and
its association with genetic alteration of MMR
genes During the first year of study, we
collected 60 pairs of tissues, performed
microsatellite of several markers in part of the samples, and obtained some findings.
Analysis of MMR genes is undergoing.
Subjects
microsatellite
mutation
mismatch
repair
repair
oxidative DNA damage
lung cancer
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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