Micronization of D-isoascorbic Acid, Propyl Gallate and Curcumin by Supercritical Anti-solvent Method
Date Issued
2010
Date
2010
Author(s)
Chang, Chiung-Yun
Abstract
In this study, micronization of antioxidant, including D-isoascorbic acid, propyl gallate, and natural colorant curcumin has been successfully performed by using the Supercritical Antisolvent (SAS) method. The aim of this research was to increase the antioxidant activity of antioxidant after the SAS process. The parameters such as temperature, pressure, solution flow rate, solution concentration and nozzle diameter were discussed in order to find the optimal operating condition for micronization.
For D-isoascorbic acid, the optimal result was obtained under the following conditions: solvent = acetone, T = 35 ℃, P = 100 bar, solution flow rate = 1mL/min, concentration = 5 mg/mL, nozzle diameter = 200 μm. The mean particle size was decreased from 101 μm to 3.30 μm. In the antioxidant activity test, the antiradical efficiency was increased about 1.64 times.
In the second part, for propyl gallate, the optimal result was obtained under the following conditions: solvent = acetone, T = 35 ℃, P = 140 bar, solution flow rate = 1mL/min, concentration = 30 mg/mL, nozzle diameter = 100 μm. The mean particle size was decreased from 531.13 μm to 7.70 μm. In the antioxidant activity test, the antiradical efficiency was increased about 1.93 times.
For curcumin, the optimal result was obtained under the following conditions: solvent = ethyl acetate, T = 35 ℃, P = 100 bar, solution flow rate = 5 mL/min, concentration = 12 mg/mL, nozzle diameter = 200 μm. The mean particle size was decreased from 17.74 μm to 2.78 μm. When changing the concentration to 10 mg/mL and fixing other parameters, the spherical particles could be obtained.
Subjects
micronization
SAS
D-isoascorbic acid
propyl gallate
curcumin
DPPH
Type
thesis
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