Inadequate humoral immunogenicity to recombinant hepatitis B virus vaccine in biliary atresia children
Journal
Pediatric Research
Journal Volume
64
Journal Issue
1
Pages
100-104
Date Issued
2008
Abstract
This study aimed to investigate the primary immunogenicity and the long-term efficacy of recombinant hepatitis B virus (HBV) vaccine in biliary atresia (BA) children. Fifty BA infants (age, 11 ± 3.9 mo), and 23 BA patients at childhood (age, 8.5 ± 0.22 y) were included for the evaluation of HBV surface antibody (anti-HBs) levels after three doses of recombinant HBV vaccine immunization. Age- and gender-matched healthy infants (n = 50) and children (n = 23) were enrolled as the control group. Serum samples of the study populations were collected for HBV seromarkers determination. In the absence of hepatitis B virus core antibody and HBV surface antigen, serum anti-HBs level above 10 IU/L was considered adequate immunogenicity to HBV vaccine. The prevalence of adequate anti-HBs levels after recombinant HBV vaccine in BA infants was significantly lower than those of the controls (p = 0.006). There was no difference in the prevalence between childhood BA patients and their matched controls (p = 0.538). In conclusion, adequate primary humoral immunity after the standard doses of recombinant HBV vaccine in BA infants is hard to establish. However, once immunity is acquired, BA children have adequate anti-HBs titer in the long run. Copyright ? 2008 International Pediatric Research Foundation, Inc.
SDGs
Other Subjects
hepatitis B antibody; hepatitis B vaccine; membrane antigen; hepatitis B antibody; hepatitis B vaccine; recombinant vaccine; article; bile duct atresia; child; childhood; clinical evaluation; control group; controlled study; drug efficacy; female; hepatitis B; Hepatitis B virus; human; humoral immunity; immunization; immunogenicity; infant; major clinical study; male; population; preschool child; prevalence; priority journal; school child; serology; virus core; antibody production; bile duct atresia; blood; case control study; cross-sectional study; immunology; nutritional status; time; Antibody Formation; Biliary Atresia; Case-Control Studies; Child; Cross-Sectional Studies; Female; Hepatitis B Antibodies; Hepatitis B Vaccines; Humans; Immunization Schedule; Infant; Male; Nutritional Status; Time Factors; Vaccines, Synthetic
Type
journal article