Traceable self-assembly of laser-triggered cyanine-based micelle for synergistic therapeutic effect
Journal
Advanced Healthcare Materials
Journal Volume
4
Journal Issue
6
Pages
892-902
Date Issued
2015
Author(s)
Abstract
To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near-infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (PCL) (mPEG-Cy-PCL) are synthesized. mPEG-Cy-PCL are capable of performing NIRF imaging, photothermal therapy (PTT) on cancer cells and self-assembly nanocarriers. Cy-based micelles can encapsulate doxorubicin (Doxo@Cy-micelle) and achieve NIRF image-guided drug delivery. Doxo@Cy-micelles are nanosized micelles enhancing the accumulation of Doxo in tumor sites and decreasing side effects. Doxo@Cy-micelles exhibit an excellent PTT and synergistic chemotherapy of cancer via laser-triggered release of Doxo from micelles, eventually resulting in decreased cancer recurrence rates. The results show that Cy-based micelles are excellent nanocarriers for NIRF imaging and synergistic photothermal-chemotherapy of cancer. Doxo@Cy-micelle based on the novel amphiphilic copolymer, methoxy poly-(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (mPEG-Cy-PCL), is simultaneously used for tracking and NIRF image-guided drug delivery. The obtained Doxo@Cy-micelles exhibit the laser-triggered release of Doxo and an excellent synergistic effect for the combined phototherapy and chemotherapy of cancer. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
Amphiphilic copolymers; Laser-triggered; Micelles; NIR fluorescence imaging; Photothermal-chemotherapy
SDGs
Other Subjects
Chemotherapy; Controlled drug delivery; Diseases; Ethylene glycol; Fluorescence imaging; Infrared devices; Polyethylene glycols; Polyols; Self assembly; Targeted drug delivery; Amphiphilic co-polymers; Image guided drug deliveries; Laser triggered; Methoxypolyethylene glycol; Near-infrared fluorescence; Nir fluorescence imaging; Photo-thermal; Poly (epsiloncaprolactone); Micelles; amphophile; copolymer; cyanine dye; doxorubicin; methoxy poly(ethylene glycol) cyanine poly(epsilon caprolactone); nanocarrier; nanoparticle; unclassified drug; carbocyanine; micelle; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer cell; cancer chemotherapy; cancer recurrence; drug binding site; drug delivery system; drug release; female; fluorescence imaging; human; human cell; laser; micelle; mouse; nanoencapsulation; near infrared fluorescence imaging; nonhuman; particle size; phototherapy; priority journal; recurrence risk; animal; chemistry; laser; nude mouse; Animals; Carbocyanines; Lasers; Mice; Mice, Nude; Micelles
Publisher
Wiley-VCH Verlag
Type
journal article