Mild cognitive impairment in combination with comorbid diabetes mellitus and hypertension is negatively associated with health-related quality of life among older persons in Taiwan
Journal
Quality of Life Research
Journal Volume
28
Journal Issue
5
Pages
1281-1291
Date Issued
2019
Author(s)
Abstract
Purpose: To fill the gap in knowledge about associations of health-related quality of life (HRQoL) with comorbid diabetes mellitus (DM), hypertension (HTN), and/or mild cognitive impairment (MCI) in the elderly, we explored associations of comorbid DM, HTN, and/or MCI with HRQoL. Methods: Data for this study were from a population-based cross-sectional survey of elderly Taiwanese (? 65?years old). Participants (N = 4,634; 47.9% male) were categorized into eight chronic-illness groups: DM only (n = 224); HTN only (n = 1226); DM and HTN (n = 365); MCI only (n = 497); DM and MCI (n = 58); HTN and MCI (n = 303); DM, HTN, and MCI (n = 101); and none (healthy; n = 1860). Associations were examined between the eight chronic-illness groups and HRQoL (measured by EQ-5D scores) using binary logistic regression analyses and generalized linear models adjusted for covariates. Index scores were calculated from EQ-5D scores using Taiwan’s general population-preference weights. Results: Compared to the healthy group, after adjusting covariates, MCI alone or with other comorbidities was significantly, negatively associated with HRQoL. Among all chronic-illness groups, comorbid DM, HTN, and MCI exhibited the lowest HRQoL. After adjusting covariates, between-group odds ratios for index scores were significant when comparing comorbid DM and MCI to DM only, comparing comorbid HTN and MCI to HTN only and comorbid DM, comparing HTN and MCI to comorbid DM and HTN, suggesting that MCI additively affects HRQoL. Conclusions: HRQoL of older Taiwanese adults was negatively associated with having MCI. Thus, clinicians managing older persons with chronic illnesses should assess their cognitive function to identify high-risk groups needing HRQoL assistance. ? 2019, Springer Nature Switzerland AG.
SDGs
Other Subjects
aged; anxiety disorder; Article; comorbidity; controlled study; cross-sectional study; depression; diabetes mellitus; European Quality of Life 5 Dimensions questionnaire; female; human; hypertension; major clinical study; male; mild cognitive impairment; priority journal; quality of life; sleep quality; adult; chronic disease; cognition; cognitive defect; comorbidity; complication; diabetes mellitus; hypertension; middle aged; pathology; physiology; psychology; quality of life; statistical model; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Chronic Disease; Cognition; Cognitive Dysfunction; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Linear Models; Male; Middle Aged; Quality of Life; Taiwan
Publisher
Springer International Publishing
Type
journal article