The role of the VEGF-C/VEGFR-3 axis in cancer progression
Journal
British Journal of Cancer
Journal Volume
96
Journal Issue
4
Pages
541-545
Date Issued
2007
Abstract
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression. ? 2007 Cancer Research.
Subjects
Lymphangiogenesis; Metastasis; VEGF-C; VEGFR-3
SDGs
Other Subjects
vasculotropin C; vasculotropin receptor 3; cancer cell; cancer growth; cell function; cell invasion; cell motility; cell proliferation; human; lymphangiogenesis; metastasis; molecular dynamics; nonhuman; priority journal; protein expression; protein function; short survey; signal transduction; tumor cell; Disease Progression; Humans; Leukemia; Lymphangiogenesis; Neoplasms; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor Receptor-3
Type
journal article