Acute and late coronary outcomes in 1073 patients with Kawasaki disease with and without intravenous γ-immunoglobulin therapy
Journal
Archives of Disease in Childhood
Journal Volume
100
Journal Issue
6
Pages
542-547
Date Issued
2015
Author(s)
Abstract
Objective: To explore acute and late coronary outcomes and their risk/modifiers in patients with Kawasaki disease (KD). Design: Retrospective study. Setting and patients: 1073 patients with KD identified from a tertiary care medical centre (1980- 2012; 8677 patient-years). Main outcome measures: The acute coronary severities and late outcomes (survival free of coronary aneurysm persistence and ischaemia) were assessed. Results: Coronary arterial lesions occurred in 40.6% of cases at their acute febrile stages, and persisted beyond 1 month in 196 (18.3%, M/F=138/58) patients: 125 (11.6%) had small aneurysms, 44 (4.1%) had medium aneurysms, and 27 (2.5%) had giant aneurysms. At follow-up (1-46 years), coronary aneurysms persisted in all with giant aneurysms, in 55% of those with medium aneurysms (18% with stenosis), and in 9% of those with small aneurysms. Ischaemia events occurred in 14 patients (M/F=13/1) and caused four deaths. Among the patients with KD with coronary aneurysms, 10-year ischaemia event-free and aneurysm persistence probability was 87.5% and 20.6%, respectively. The only independent risk for aneurysm persistence was the aneurysm severity 1 month after KD onset (Χ2=80.73, p< 10-3). Male patients and intravenous γ-immunoglobulin (IVIG) therapy were independent risk factors of initial coronary severity but were not associated with the late coronary outcomes, even in severity stratified subgroups. Conclusions: The coronary severity 1 month after KD onset is most crucial to the late coronary outcomes. Although IVIG use improves the initial severity of coronary lesions, it does not further modify the longterm fate of coronary aneurysms.
SDGs
Other Subjects
immunoglobulin; immunoglobulin; adolescent; adult; adverse outcome; artery lesion; Article; child; coronary artery aneurysm; coronary artery disease; disease severity; event free survival; female; fever; follow up; heart muscle ischemia; human; immunotherapy; infant; longitudinal study; major clinical study; male; mucocutaneous lymph node syndrome; observational study; priority journal; retrospective study; risk assessment; sex difference; survival rate; aged; complication; coronary artery disease; coronary blood vessel; mucocutaneous lymph node syndrome; pathology; risk factor; treatment outcome; Aged; Coronary Artery Disease; Coronary Vessels; Female; Humans; Immunoglobulins, Intravenous; Male; Mucocutaneous Lymph Node Syndrome; Retrospective Studies; Risk Factors; Treatment Outcome
Publisher
BMJ Publishing Group
Type
journal article