Dual Polarisation Interferometry for Measurement of Biomolecule at Nanometer Scale
Other Title
雙偏極化干涉術－生物分子奈米量測
Journal
Instruments Today
Journal Issue
144
Start Page
55
End Page
62
Date Issued
2005
Author(s)
Abstract
近十幾年以來，以表面電漿共振技術即時量測分子動力學之應用已非常廣泛，而英國Farfield Sensor公司所研發生產的最新量測儀器，藉由雙偏極化干涉法的分析技術，可量測分子直徑、厚度、密度、表面濃度和動力學參數等多種固－液介面薄膜即時的反應和變化，解析度達原子層級(Å)，其應用範圍包括單分子結構及構形變化、分子－分子間相互作用、奈米分子醫學診斷以及奈米科技之應用等。雙偏極化干涉儀之發明有助於突破現階段蛋白質結構與小分子研究之瓶頸。
From decade the application of surface plasmon resonance technique was broadly on molecular dynamics, however, Fairfield Sensor invented the new method, dual polarisation interferometry, which is used on analysis of changes of diameter, thickness, density, surface concentration, and dynamics on solid-liquid interface at real time. The application of dual polarisation interferometer includes single molecule structure and conformation change, interactions between molecules, nanomedicine diagnosis, and nano-technology etc. The invention of dual polarisation interferometer proves the study on molecular structure conforfation change.
Type
journal article