Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics
Journal
Molecular cytogenetics
Journal Volume
10
Journal Issue
1
Date Issued
2017
Author(s)
Huang, Chung-Er
Ma, Gwo-Chin
Jou, Hei-Jen
Lin, Wen-Hsiang
Lee, Dong-Jay
Lin, Yi-Shing
Ginsberg, Norman A
HSIN-FU CHEN
Chang, Frank Mau-Chung
MING CHEN
Abstract
Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as "Cell Reveal™" to demonstrate the feasibility of capturing circulating fetal nucleated red blood cells (fnRBC) and extravillous cytotrophoblasts (EVT) for cell-based noninvasive prenatal diagnosis (cbNIPD).
Subjects
Aneuploidy; EVT; Fish; NGS; NIPT; aCGH; cbNIPD; fnRBC
SDGs
Publisher
BMC
Type
journal article