台灣烏腳病流行區泌尿系統移形上皮癌生物分子學之探討研究─台灣西南沿海地區泌尿道移形上皮細胞癌之分子流行病學研究(3/3)

In order to compare the chromosomal imbalances between
arsenic-induced and non-arsenic-induced TCC, we analyzed 24
arsenic-induced and 25 non-arsenic-induced TCC by comparative
genomic hybridization. More arsenic-induced TCCs had at least one
chromosomal imbalance (100%) than non-arsenic- induced TCCs (70%).
The number of chromosomal imbalances (mean + standard error) was
also significantly higher in the arsenic- induced TCCs (5.7+0.6) than
non-arsenic-induced TCCs (2.9+0.5). Arsenic exposure is significantly
associated with an increased number of chromosomal imbalances after
adjustment for cigarette smoking and grade and stage of TCCs in the
multiple linear regression analysis. We also found a significantly higher
frequency of chromosome gains at 1p12-13, 3q24-25, 4q12-13, 7q112
and 8q22 in arsenic-induced TCCs than in non-arsenic-induced ones. In
addition, the frequency of chromosome losses in 16p132-p133 and
17p13 was also significantly higher in arsenic-induced TCCs than non-arsenic-induced ones.