B型肝炎病毒基因型及表面抗原T細胞抗原決定部位基因變異慢性B型肝炎病毒感染病程的影響(2/3)
Date Issued
2003
Date
2003
Author(s)
張美惠
DOI
912314B002149
Abstract
The aims of this study are (1) to investigate the role of mutation at the HLAclass
I restricted T cell epitope and B cell epitope of hepatitis B surface antigen
(HBsAg) gene in the natural course of children with chronic hepatitis B virus ( HBV)
infection with and
without hepatocellular carcinoma (HCC), and (2) to compare the mutation rates at the
T cell epitope and the B cell epitope in children with chronic HBV infection and HCC
with and without hepatitis B immunoprophylaxis in infancy.
We have longitudinally followed 97 HBsAg carrier children, 53 did and 44 did
not receive hepatitis B immunoprophylaxis during infancy. T cell epitope amino acids
28-51 at the HBV surface gene has been studied in those 97 children and another 15
children with HBV related HCC. Children with HCC showed a significantly higher
rate of T cell epitope mutation at amino acid residue 40-49 than children without HCC
(46.7% v.s. 6.2%, p=0.0013). No difference in the rate of B cell epitope mutation was
found between children with and without HCC (p > 0.1). A trend of higher mutation
rate in the B-cell epitope was observed in children who received HBV vaccination
than in children without vaccination (22.4% v.s. 9.3%, p=0.063). No difference in the
mutation rate at T cell epitope domain of the HBsAg gene was found between those
who were unvaccinated and those who were vaccinated during infancy (p > 0.1 ).
In conclusion, Mutations at the T cell epitope amino acid residue 40-49 were
much more frequently found in childhood HCC than HBV carriers children. Its
relationship with early hepatocarcinogenesis requires further investigation.
Subjects
chronic hepatitis B virus infection
hepatocellular carcinoma in children
T cell epitope on hepatitis B surface gene
B cell epitope on hepatitis B
surface gene
surface gene
SDGs
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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