The prognostic value of the simplified comorbidity score in the treatment of small cell lung carcinoma
Journal
Journal of Thoracic Oncology
Journal Volume
6
Journal Issue
2
Pages
378-383
Date Issued
2011
Abstract
Comorbidity may be an important prognostic factor in the treatment of small cell lung carcinoma (SCLC). This study aimed to investigate the prognostic values of simplified comorbidity score (SCS) in the treatment of patients with SCLC. Methods: The patients with SCLC admitted to the National Taiwan University Hospital during the period from January 2000 to December 2006 were included. The medical records were reviewed and analyzed. The SCS was used to evaluate comorbidities of the patients. A Cox proportional hazard model was used to calculate the hazard ratio (HR) and 95% confidence intervals (CIs) for age, gender, and factors significantly associated with survival identified in univariate analyses. Results: A total of 172 patients were included; 56 patients had limited-stage disease and 116 had extensive-stage disease. Patients with an SCS more than 9 had shorter overall survival than those with SCS ?9 both in limited-stage (372 days versus 581 days, p = 0.01) and extensive-stage disease (215 days versus 324 days, p = 0.001). Multivariate analysis indicated that SCS more than 9 was associated with a worse prognosis in patients with limited-stage disease (HR: 2.17, 95% CI: 1.12-4.21) and extensive-stage disease (HR: 1.74, 95% CI: 1.12-2.72), respectively. For patients with extensive-stage disease, SCS more than 9 was associated with poor treatment response (>9 versus ?9, disease response rate: 60.0% versus 82.4%, p = 0.02). Conclusions: The SCS may be an independent prognostic factor for patients with SCLC. Large-scale prospective studies may be required to validate the prognostic value of the SCS for SCLC. Copyright ? 2011 by the International Association for the Study of Lung Cancer.
SDGs
Other Subjects
antineoplastic metal complex; cyclophosphamide; doxorubicin; vincristine; adult; aged; alcoholism; article; cancer staging; cancer survival; cardiovascular disease; chronic obstructive lung disease; comorbidity; diabetes mellitus; female; gender; hospital admission; human; kidney failure; lung disease; lung non small cell cancer; lung small cell cancer; major clinical study; male; medical record review; neoplasm; overall survival; priority journal; prognosis; scoring system; tobacco
Publisher
Lippincott Williams and Wilkins
Type
journal article