Charge Dependence on the Transdermal Iontophoretic Delivery Revealed by Multiphoton Microscopic Imaging
Date Issued
2005
Date
2005
Author(s)
Chen, Jie
DOI
zh-TW
Abstract
In this thesis we utilize multiphoton microscope as a tool to investigate an enhancement method of transdermal
delivery system, that is, iontophoresis. We choose the
charge carried by fluorescent model drugs as a varient
factor. We study the dependence of molecular charge in
transdermal iontophoretic molecular delivery. We chose
6,8-dihydroxy-1,3-pyrenedisulfonic acid disodium salt, 8-
hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt, and
calcein with the respective charges of -2, -3, and -4. These
molecules are used as model drugs to probe the difference
in iontophoretic delivery pathways when using molecules
with different charges. Because of the visualization ablilty
of fluorescent microscopy, it becomes able for us to observe
the distribution of model drug inside the skin tissue,
which is different from the traditional ways used for
this experiment. The result shows that the charge of the
molecules can affect the delivery efficiency and the delivery path, and is of physical meaning.
Subjects
雙光子顯微術
離子導入術
皮膚
multiphoton microscopy
iontophoresis
transdermal delivery
Type
thesis
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