Impact of varying anatomic sites on advanced stage and survival of oral cancer: 9-year prospective cohort of 27 717 cases
Journal
Head and Neck
Journal Volume
41
Journal Issue
5
Pages
1475-1483
Date Issued
2019
Author(s)
Su W.W.-Y.
Su C.-W.
Chang D.-C.
Chuang S.-L.
Chen S.L.-S.
Hsu C.-Y.
Yen A.M.-F.
Chiu S.Y.-H.
Fann J.C.-Y.
Lee Y.-H.
Jeng Y.-C.
Chen M.-K.
Abstract
Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance. ? 2019 Wiley Periodicals, Inc.
SDGs
Other Subjects
adult; advanced cancer; age; anatomical concepts; Article; betel quid; cancer staging; cancer survival; cigarette smoking; cohort analysis; female; follow up; gingiva; hard palate; human; lip cancer; major clinical study; male; middle aged; mouth cancer; oropharynx; oropharynx cancer; priority journal; prospective study; sex difference; Taiwan; tongue cancer; adverse event; aged; alcoholism; cause of death; cheek; comparative study; complication; confidence interval; disease free survival; early cancer diagnosis; mortality; mouth floor; mouth tumor; odds ratio; pathology; procedures; risk assessment; smoking; survival analysis; tumor invasion; young adult; Adult; Aged; Alcoholism; Cause of Death; Cheek; Cohort Studies; Confidence Intervals; Disease-Free Survival; Early Detection of Cancer; Female; Gingiva; Humans; Male; Middle Aged; Mouth Floor; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Odds Ratio; Oropharynx; Palate, Hard; Prospective Studies; Risk Assessment; Smoking; Survival Analysis; Taiwan; Young Adult
Publisher
John Wiley and Sons Inc.
Type
journal article