Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
Journal
Journal of Natural Products
Journal Volume
65
Journal Issue
12
Pages
1904-1908
Date Issued
2002
Author(s)
Abstract
Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.
Other Subjects
dichloromethane; diterpenoid; norditerpenoid; scabrolide; unclassified drug; article; cancer cell; cell line; controlled study; coral; cytotoxicity; epimer; extract; human; human cell; isolation procedure; metabolite; nuclear Overhauser effect; structure analysis; Taiwan; Animals; Anthozoa; Diterpenes; Drug Screening Assays, Antitumor; Gas Chromatography-Mass Spectrometry; Humans; KB Cells; Methylene Chloride; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Sinularia
Type
journal article