Clinicopathological features and prognosis of patients with de novo versus nevusassociated melanoma in Taiwan
Journal
PLoS ONE
Journal Volume
12
Journal Issue
5
Pages
e0177126
Date Issued
2017
Author(s)
Lin M.-H.
Liang C.-W.
Abstract
Studies surveying melanomas associated with melanocytic nevi in Asia are rare. In this study, we examined whether nevus-Associated melanomas differ from de novo melanomas in terms of their associations with clinical factors, histologic characteristics, and patient survival in Taiwan. Using data on cancer cases obtained from the Department of Pathology archives and the Cancer Registry of National Taiwan University Hospital, we conducted a retrospective analysis of 103 consecutive melanoma patients who were diagnosed between 2010 and 2015 and received follow-up through November 2016. Approximately 17.5% of the melanomas in question were associated with a nevus. In patients under 65 years of age, non-Acral lentiginous melanomas were significantly associated with a higher percentage of nevus-Associated melanomas. The superficial spreading subtype, younger patient age, thinner tumor, intermittent solar exposure, and early stage were significant predictors of a melanoma being histologically associated with a nevus. The appearance of a nevus associated with a melanoma predicted better recurrence-free survival compared with de novo melanomas. Although acral lentiginous melanomas (70.9%) constituted the most common histologic subtype, only 9.6% of the acral lentiginous melanomas were associated with a nevus. Furthermore, there was no statistically significant difference between the nevusassociated and de novo acral lentiginous melanomas with regard to clinicopathological factors and survival. In conclusion, nevus-Associated melanomas were uncommon among acral lentiginous melanomas. Relatedly, because over half of all melanomas in Asians are acral lentiginous melanomas, Asians are less likely than Caucasians to have nevus-Associated melanomas. ? 2017 Sheen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SDGs
Other Subjects
adult; aged; Article; Asian; cancer classification; cancer prognosis; cancer registry; cancer staging; Caucasian; clinical feature; clinical protocol; cohort analysis; controlled study; disease duration; distant metastasis free survival; female; histopathology; human; lymph vessel metastasis; major clinical study; male; melanoma; middle aged; nevus; overall survival; recurrence free survival; retrospective study; tumor volume; very elderly; young adult; melanoma; nevus; pathology; Skin Neoplasms; survival analysis; Taiwan; Aged; Female; Humans; Male; Melanoma; Middle Aged; Nevus; Skin Neoplasms; Survival Analysis; Taiwan
Publisher
Public Library of Science
Type
journal article