Aurora A and NF-κB survival pathway drive chemoresistance in acute myeloid leukemia via the TRAF-interacting protein TIFA
Journal
Cancer Research
Journal Volume
77
Journal Issue
2
Pages
494-508
Date Issued
2017
Author(s)
Wei T.-Y.W.
Wu P.-Y.
Wu T.-J.
Teng C.-L.J.
Lin C.-R.
Chen J.-M.M.
Lin T.-Y.
Su H.-C.
Huang C.-C.F.
Yu C.-T.R.
Hsu S.-L.
Tsai M.-D.
Abstract
of chemotherapeutic drug treatments in AML cells. Furthermore, in vivo delivery of TIFA-inhibitory fragments potentiated the clearance of myeloblasts in the bone marrow of xenograft-recipient mice via enhanced chemotoxicity. Collectively, our results showed that TIFA supports AML progression and that its targeting can enhance the efficacy of AML treatments. Cancer Res; 77(2); 494-508. ©2016 AACR.
SDGs
Publisher
American Association for Cancer Research Inc.
Type
journal article