Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: A systematic review and meta-analysis
Journal
PLoS ONE
Journal Volume
9
Journal Issue
10
Pages
e110569
Date Issued
2014
Author(s)
Weng P.-H.
Huang Y.-L.
Page J.H.
Xu J.
Koutros S.
Berndt S.
Chanock S.
Yeager M.
Witte J.S.
Eeles R.A.
Easton D.F.
Neall D.E.
Donovanl J.
Hamdyl F.C.
Muir K.R.
Giles G.
Severi G.
Smith J.R.
Balistreri C.R.
Shui I.M.
Abstract
Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa. ? 2014 Weng et al.
SDGs
Other Subjects
cancer risk; controlled study; disease association; gene frequency; genetic association; genetic risk; genotype; human; innate immunity; major clinical study; prostate cancer; receptor gene; Review; risk assessment; single nucleotide polymorphism; systematic review; TLR4 gene; genetic predisposition; genetics; genome-wide association study; immunology; male; meta analysis; pathology; prostate tumor; TLR4 protein, human; toll like receptor 4; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Immunity, Innate; Male; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Toll-Like Receptor 4
Publisher
Public Library of Science
Type
review