CBAP as a Prognostic Marker of Ovarian Epithelial Carcinoma
Date Issued
2016
Date
2016
Author(s)
Ou, Cheng-Miao
Abstract
The purpose of the study was to investigate the relationship between CBAP expression levels and the clinico-pathologic parameters of ovarian epithelial carcinoma patients. In addition, whether CBAP could be a biomarker of chemo-response and prognosis was also evaluated. Totol 257 women were enrolled in the study, including 223 ovarian epithelial carcinoma patients, 24 benign ovarian epithelial carcinoma patients, and 10 menopausal women without definite ovarian lesions. The CBAP expressions were determined by Quantitative real-time polymerase chain reaction (QT-PCR), polymerase chain reaction (PCR), and immunoblotting respectively. The correlations between clinico-pathologic parameters and outcome of these ovarian patients were also analyzed. The expression levels of CBAP were higher in cancerous tissues than those in benign ovarian and normal ovarian samples. Patients with advanced stages, high grade tumors, or chemo-resistance had significantly higher CBAP expression levels compared to those with early stages, low grade tumors, or chemo-sensitive. The advanced stages, residual tumor size ≥1cm after debucking surgery, and highly-expressing CBAP in cancerous tissues were independent poor prognostic factors for progression free survival (PFS) and overall survival (OS) by using multi-variate analysis. In conclusion, CBAP can be a potential biomarker for predicting the chemotherapeutic responses and outcomes of ovarian epithelial carcinoma patients.
Subjects
biomarker
ovarian epithelial carcinoma
quantitative real-time PCR
PCR
western blot
progression free survival
overall survival
SDGs
Type
thesis
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