SULT1A1 polymorphism and esophageal cancer in males
Journal
International Journal of Cancer
Journal Volume
103
Journal Issue
1
Pages
101-104
Date Issued
2003
Author(s)
Abstract
Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULTIA I his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G→A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p > 0.0001). No subjects carried his/his. After adjusting for substane use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non-smokers, non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his213 allele is important in the development of esophageal cancer in men. ? 2002 Wiley-Liss, Inc.
SDGs
Other Subjects
arginine; histidine; protein SULT1A1; sulfotransferase; unclassified drug; adult; aged; alcohol consumption; allele; amino acid substitution; article; betel nut; cancer risk; cigarette smoking; clinical trial; controlled clinical trial; controlled study; covariance; disease course; enzyme polymorphism; esophagus carcinoma; genotype; human; major clinical study; male; multicenter study; priority journal; risk assessment; risk factor; squamous cell carcinoma; substance abuse; Adult; Aged; Aged, 80 and over; Alleles; Arylsulfotransferase; Carcinoma, Squamous Cell; Case-Control Studies; DNA Primers; Esophageal Neoplasms; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Smoking; Sulfotransferases
Type
journal article