Neuroimaging findings in children with paediatric neurotransmitter diseases
Journal
Journal of Inherited Metabolic Disease
Journal Volume
32
Journal Issue
3
Pages
361-370
Date Issued
2009
Author(s)
Abstract
Paediatric neurotransmitter diseases consist of a group of inherited neurometabolic diseases in children, and include disorders related to γ-amino butyric acid (GABA) metabolism, monoamine biosynthesis, etc. The diagnosis of paediatric neurotransmitter diseases remain a great challenge for paediatricians and child neurologists. In addition to clinical manifestations and CSF neurotransmitter measurement, neuroimaging findings can also be very informative for the diagnosis and evaluation of the patients. For patients with monoamine biosynthesis disorders, the functional evaluation of dopaminergic transmission also plays an important role. Understanding of the possible neuroimaging changes in paediatric neurotransmitter diseases is therefore of great value for the investigation of these patients. ? Springer Science+Business Media B.V. 2009.
SDGs
Other Subjects
4 aminobutyric acid; 6 fluorodopa f 18; [2 [[2 [[[3 (4 chlorophenyl) 8 methyl 8 azabicyclo[3.2.1]oct 2 yl]methyl](2 mercaptoethyl)amino]ethyl]amino]ethanethiolato]oxotechnetium tc 99m; aromatic levo amino acid decarboxylase; carbon 11; dihydrotetrabenazine; fluorodeoxyglucose f 18; iodine 123; methylphenidate; monoamine; n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 6 methoxysalicylamide; neurotransmitter; sepiapterin reductase; succinate semialdehyde dehydrogenase; tyrosine 3 monooxygenase; 4 aminobutyric acid metabolism; aromatic levo amino acid decarboxylase deficiency; autosomal disorder; cerebrospinal fluid level; childhood disease; clinical evaluation; clinical feature; conference paper; dopaminergic transmission; enzyme deficiency; human; metabolic disorder; monoamine metabolism; neuroimaging; neurologic disease; nonhuman; pediatric neurotransmitter disease; pediatrician; positron emission tomography; Segawa disease; sepiapterin reductase deficiency; succinate semialdehyde dehydrogenase deficiency; tyrosine hydroxylase deficiency; Alcohol Oxidoreductases; Aromatic-L-Amino-Acid Decarboxylases; Brain; Brain Diseases, Metabolic, Inborn; Child; Diagnostic Imaging; Diagnostic Techniques, Neurological; Humans; Models, Biological; Neurotransmitter Agents; Succinate-Semialdehyde Dehydrogenase; Tyrosine 3-Monooxygenase
Type
conference paper