Risk factors for bacteraemia and endovascular infection due to non-typhoid salmonella: A reappraisal
Journal
QJM - Monthly Journal of the Association of Physicians
Journal Volume
98
Journal Issue
11
Pages
821-827
Date Issued
2005
Author(s)
Lin F.-Y.
Abstract
Background: Endovascular infections are rare complications of non-typho id salmonellosis. The diagnosis is frequently not established until the infection is advanced. It is important to identify high-risk patients and treat them as early as possible. Aim: To identify risk factors for bacteraemia and endovascular infection in patients with non-typhoid salmonellosis. Design: Retrospective study. Setting: A single tertiary-care hospital in Taiwan. Methods: Data were collected by retrospective chart review. Log-logistic regression modelling was used to identify independent risk factors for bacteraemia and endovascular infection. We analysed the characteristics of patients with gastroenteritis vs. those with bacteraemia, and of bacteraemic patients with vs. without endovascular infection. Results: Between 1984 and 2004, there were 373 adult cases of non-typhoid salmonellosis. There were 76 intestinal Salmonella infections, 290 bloodstream infections (including 47 endovascular infections), and 7 extra-intestinal non-bacteraemic infections. The independent positive predictors of bacteraemia were systemic lupus erythematosus, liver cirrhosis, HIV infection, and solid organ cancers. The only independent positive predictor of endovascular infection was atherosclerosis. The independent negative predictors of endovascular infection were solid organ cancers and immunodeficiency. Discussion: Risk factors for atherosclerosis predisposed our patients with bacteraemia to endovascular infection. Although immunodeficiency predisposed patients to bacteraemia, it was associated with a low incidence of endovascular infection. ? The Author 2005. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.
SDGs
Other Subjects
adult; aged; article; atherosclerosis; bacteremia; controlled study; disease association; disease predisposition; endovascular infection; female; gastroenteritis; human; immune deficiency; infection complication; infection risk; liver cirrhosis; logistic regression analysis; major clinical study; male; prediction; priority journal; retrospective study; risk assessment; risk factor; Salmonella; salmonellosis; solid tumor; statistical model; systemic lupus erythematosus; Taiwan; time series analysis; Adult; Aged; Atherosclerosis; Bacteremia; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Salmonella Infections; Taiwan
Type
journal article