A comparative study on cannabidiol-induced apoptosis in primary and transformed immune cells
Date Issued
2008
Date
2008
Author(s)
Lee, Chi-Ya
Abstract
Drug abuse is a global problem, and marijuana is one of the most commonly abused drugs. CBD is the major non-psychoactive phytocannabinoids contained in marijuana, which lacks significant binding affinity to CB1 and CB2 receptors. Many reports showed that CBD exerted a growth inhibitory effect on various cancer cells, such as glioma, leukemia and breast carcinoma, whereas CBD did not affect their primary counterparts, such as glia cells and monocytes. These results suggest that CBD may be used as a potential anti-cancer agent. However, little information pertaining to the immunomodulatory effects of CBD is available. Previous studies from our laboratory have demonstrated that CBD exhibited a broad spectrum of immunosupressive effects on humoral responses in ovalbumin-sensitized BALB/c mice, including the production of antigen-specific IgM, IgG1 and IgG2a. In addition, the production of cytokines, including IL-2, IL-4 and IFN-
Subjects
cannabidiol
apoptosis
thymocytes
EL-4
monocytes
oxidative stress
SDGs
Type
thesis
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