The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats
Journal
Veterinary Ophthalmology
Journal Volume
15
Journal Issue
SUPPL.2
Pages
65-71
Date Issued
2012
Author(s)
Abstract
The effects of Lycium barbarum and Chrysanthemum morifolum extracts on diabetic retinopathy were evaluated. The diabetes model was induced by streptozotocin. Animals were divided into six groups: the control group received only vehicle; diabetic animal models received no treatment, insulin treatment, Lycium extract, Chrysanthemum extract, or a combination of Lycium and Chrysanthemum extracts, respectively. Retinal function was evaluated by electroretinography, and the diabetic progression was monitored by blood test for hyperglycemia. In addition, retinal histopathology and retinal glial reactivity were also investigated. The electroretinographic amplitudes of the a- and b-waves were significantly decreased in the diabetic animals, and the implicit time of the b-wave was also delayed, compared to the control group. However, reductions in the a- and b-wave amplitudes were not observed in the Lycium-treated group. Histopathological studies showed no significant differences between the Lycium-treated, Chrysanthemum-treated, Lycium/Chrysanthemum-treated groups, and the control group. The results of this study suggest that L. barbarum may have protective effects in diabetic retinopathy. ? 2012 American College of Veterinary Ophthalmologists.
Subjects
Chrysanthemum morifolum; Diabetic retinopathy; Electroretinography; Lycium barbarum; Retinal protection
SDGs
Other Subjects
plant extract; animal; article; chemistry; Chrysanthemum; diabetic retinopathy; electroretinography; experimental diabetes mellitus; flower; fruit; Lycium; male; rat; Animals; Chrysanthemum; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Flowers; Fruit; Lycium; Male; Plant Extracts; Rats; Animalia; Chrysanthemum; Lycium; Lycium barbarum; Rattus
Type
journal article