Protease Purified from Schizophyllum commune Culture Broth Digests Fibrins Without Activating Plasminogen
Resource
AMERICAN JOURNAL OF CHINESE MEDICINE, 38(6), 1223-1231
Journal
The American Journal of Chinese Medicine
Pages
1223-1231
Date Issued
2010
Date
2010
Author(s)
Lu, Chung-Lun
Wang, Jeng-Pang
Chen, Shiu-Nan
Abstract
Schizophyllum commune is a widely distributed mushroom used as an herbal medicine and an ingredient in healthy food. In this study, a protease from a fermented culture broth of S. commune demonstrated strong fibrinolytic and fibrinogenolytic activities. This fibrinolytic protease showed a suppression effect in blood coagulation in co-incubation with rat citrated blood through thromboelastographic analysis. The protease suppressed aggregation of fibrin (ogen), but not the platelets, in clotting formation and significantly decreased the clot strength. We also found very little potency in this protease to activate plasminogen, thus it exhibits the potential for an ideal fibrinolytic candidate for therapeutic applications in the future.
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Type
journal article
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