Biomaterials and Stem Cells for Myocardial Repair
Part Of
Biomaterials and Stem Cells in Regenerative Medicine
Start Page
345
End Page
366
ISBN (of the container)
9781439879269
9780429066658
ISBN
9781439879269
9780429066658
Date Issued
2012-01-01
Author(s)
Abstract
Cardiovascular diseases account for 12 million deaths annually worldwide. Myocardial infarction (MI) continues to be a signicant problem in industrialized countries and is becoming an increasingly signicant problem in developing countries. MI is one of the leading causes of morbidity and mortality in the United States. Approximately 1.3 million clinical cases of nonfatal MI-an annual incidence rate of approximately 600 cases per 100, 000 people-have been reported per year (Fenton 2007). The rapid development of myocardial necrosis, due to a critical imbalance between oxygen supply and the demand of the myocardium, is one of the pathological factors leading to MI. An MI potentially results from plaque rupture with thrombus formation in a coronary artery, resulting in an acute reduction of blood supply to a portion of the myocardium (Alpert et al. 2000). Approximately 500,000-700,000 deaths are caused by ischemic heart disease annually in the United States.
Publisher
CRC Press LLC
Type
book part