Optimal timing of renal replacement therapy initiation in acute kidney injury: The elephant felt by the blindmen?
Journal
Critical Care
Journal Volume
21
Journal Issue
1
Pages
146
Date Issued
2017
Author(s)
Abstract
Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome. ? 2017 The Author(s).
SDGs
Other Subjects
catecholamine; neutrophil gelatinase associated lipocalin; acquired immune deficiency syndrome; acute kidney failure; Article; artificial ventilation; chronic kidney failure; continuous hemofiltration; continuous renal replacement therapy; controlled study; critically ill patient; disease course; disease severity; estimated glomerular filtration rate; glomerulonephritis; hepatorenal syndrome; hospital mortality; human; intensive care unit; length of stay; morbidity; mortality rate; priority journal; prognosis; randomized controlled trial; renal replacement therapy; therapy delay; treatment outcome; urea nitrogen blood level; urine volume; acute kidney failure; critical illness; organization and management; procedures; renal replacement therapy; standards; time factor; treatment outcome; Acute Kidney Injury; Critical Illness; Humans; Intensive Care Units; Renal Replacement Therapy; Time Factors; Treatment Outcome
Publisher
BioMed Central Ltd.
Type
journal article