Association between Testicular Cancer and Epididymoorchitis: A Population-Based Case-Control Study
Journal
Scientific Reports
Journal Volume
6
Pages
23079
Date Issued
2016
Author(s)
Abstract
Even though epididymoorchitis and testicular cancer (TC) may have similar pathophysiological pathways, no prior study has attempted to determine the association between these two diseases. This case-control study investigated the relationship between TC and prior epididymoorchitis by using a large population-based database. We used the Taiwan Longitudinal Health Insurance Database 2005 to select 372 patients who had received a diagnosis of TC and 3,720 age-matched controls without TC. We found that of the total sample of 4,092 patients, 53 (1.3%) had received a diagnosis of epididymoorchitis prior to the index date. Patients with TC had a higher prevalence of prior epididymoorchitis than that of patients without TC (11.0% vs. 0.3%, p < 0.001). Conditional logistic regression showed that prior epididymoorchitis was significantly associated with TC (crude OR = 38.24, 95% CI = 19.91-73.46). The association remained statistically significant even after adjustment for the other variables (OR = 47.17, 95% CI = 23.83-93.40). This study showed that patients with TC have higher odds of prior epididymoorchitis than do those without TC even after adjustment for potential confounders.
SDGs
Other Subjects
adolescent; adult; case control study; comorbidity; epididymitis; factual database; health insurance; human; male; middle aged; odds ratio; orchitis; prevalence; statistical model; statistics and numerical data; Taiwan; Testicular Neoplasms; young adult; Adolescent; Adult; Case-Control Studies; Comorbidity; Databases, Factual; Epididymitis; Humans; Insurance, Health; Logistic Models; Male; Middle Aged; Odds Ratio; Orchitis; Prevalence; Taiwan; Testicular Neoplasms; Young Adult
Publisher
Nature Publishing Group
Type
journal article