Boswellia Serrata resin extract alleviates azoxymethane/dextran sulfate sodium-induce colon tumorigenesis via inhibition of inflammation related signaling pathways
Date Issued
2016
Date
2016
Author(s)
Chou, Ya-Chun
Abstract
Colorectal cancer (CRC) become a worldwide public health problem. In the previous studies, inflammation-linked carcinogenesis is well accepted concept and is often observed. Boswellia serrata resin has been used in India traditional medicine to treat a variety of inflammatory-related diseases. The most significant components of its supercritical CO2 extraction analysis by LC-MS/MS are boswellic acids including β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid. Although boswellic acids have been shown to be potential anti-tumorigenesis phytochemicals, but their mechanisms involved are not clear. In the present study, we investigated the chemopreventive effects of a Boswellia serrata (BS) extract on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colon tumorigenesis in ICR mice. We found that the treatment with BS extract can restore the shortening of the colon length, enhance the survival rate and reduce the colonic tumor growth. Western blot and histological analysis revealed that dietary BS extract could markedly reduce the protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), mitogen-activated protein kinases (MAPKs) and nuclear expression of NF-κB. Furthermore, BS extract reduced cell proliferation via inhibiting phosphorylation level of Akt, GSK3β and downregulation of cyclin D1. In addition, we also observed the changes on colonic microbiota after fed with BS extract that enhanced the ratio of Clostridiales and decreased abundance of Bacteroidales in AOM/DSS-treated mice. These results suggest that dietary administration of BS extract may alleviate colonic tumorigenesis.
Subjects
Boswellia serrata (BS)
colorectal cancer (CRC)
inflammation
gut microbiome
SDGs
Type
thesis
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