在DOBUTAMINE催迫性檢查時的心臟整合逆散射超音波組織特性之分析
Other Title
Ultrasonic Tissue Characterization with Integrated Backscatter during Inotropi Stimulation
Date Issued
2001
Date
2001
Author(s)
高憲立
DOI
892314B002452
Abstract
Ultrasonic tissue characterization with integrated backscatter is an objective method to
quantitatively define the physical state of the myocardium. To investigate whether backscatter
imaging during inotropic stimulation could be used objectively to determine the myocardial
viability and ischemia in patients with ischemic heart disease, the backscatter changes were
examined in 23 patients with myocardial infarction during dobutamine stress two-dimentional
echocardiography. Coronary angiography was performed within 1 to 2 days after the stress test.
The results of this study demonstrated that changes in backscatter variability correlated
significantly with the wall motion changes in stress echocardiography during dobutamine
infusion (p<0.0001). In addition, it was shown that the backscatter changes were significantly
different in various types of myocardial tissue. In 23 normal control segments, the ultrasonic
backscatter variability was preserved and unchanged during inotropic stimulation (p=NS). In
15 viable infarct zones, restoration or an increase in backscatter variability during low-dose
dobutamine infusion was noted, this being lost when ischemia developing during high-dose
dobutamine infusion (p<0.01). In 9 non-viable infarct zones, the phase-weighted variation was
usually £ 0 and did not change significantly during inotropic stimulation, regardless of the
patency of the infarct-related arteries. In 15 remote ischemic myocardial zones, the backscatter
variability was preserved at the baseline level, did not changed during low-dose dobutamine
infusion, but decreased significantly during high-dose dobutamine stress (p<0.01). In
conclusion, dobutamine stress tissue characterization could offer an objective approach for the
detection of myocardial viability and ischemia, and might be a useful adjunct to the
conventional stress echocardiography.
Subjects
Ultrasonic backscatter
tissue characterization
inotropic stimulation
and ischemic
heart disease
heart disease
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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