The Role of Calreticulin in the Differentiation and Apoptosis of Neuroblastoma
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
許文明
DOI
922314B002273
Abstract
Previous studies showed that calreticulin (CRT)
played an important role in the differentiation and
apoptosis of neuroblastoma (NB). However, the
mechanism it might be involved in these processes are
not clear. This study showed that in 68 NBs, all
expressed calnexin, 32 expressed CRT, 35 expressed
Trk-A, and 40 expressed GRP78. The expression of
CRT strongly correlated with Trk-A and GRP78, but
inversely correlated with N-myc amplification. There
is a synergistic effect between CRT and Trk-A and
GRP78 on the patient survival. CRT might be
involved in the signaling pathway of Trk-A and N-myc
of NB. CRT might also share a common role with
GRP78 in NB.
Subjects
Neuroblastoma
Cell
differentiation
differentiation
Apoptosis
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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922314B002273.pdf
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