Correlation of Survival Motor Neuron Expression in Leukocytes and Spinal Cord in Spinal Muscular Atrophy
Journal
Journal of Pediatrics
Journal Volume
154
Journal Issue
2
Pages
303-305
ISSN
0022-3476
Date Issued
2009-02
Author(s)
Abstract
Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA. ? 2009 Mosby, Inc. All rights reserved.
SDGs
Other Subjects
messenger RNA; survival motor neuron protein; survival motor neuron protein 2; animal experiment; animal model; article; clinical article; controlled study; correlation analysis; correlation coefficient; disease severity; human; leukocyte; mouse; nonhuman; onset age; priority journal; protein expression; quantitative analysis; reverse transcription polymerase chain reaction; spinal cord; spinal muscular atrophy; statistical analysis; Adult; Age of Onset; Animals; Female; Humans; Leukocytes; Male; Mice; Muscular Atrophy, Spinal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SMN Complex Proteins; Spinal Cord
Type
journal article