Food Bioactives and Their Effects on Obesity-Accelerated Inflammatory Bowel Disease
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
66
Journal Issue
4
Pages
773--779
Date Issued
2018-01
Author(s)
Abstract
Current views support the concept that obesity is linked to a worsening of the course of inflammatory bowel diseases (IBDs). Gut microbiota and adipose tissue macrophage (ATM) are considered key mediators or contributors in obesity-associated intestinal inflammation. Dietary components can have direct or indirect effects on "normal" or "healthy" microbial composition and participate in adiposity and metabolic status with gut inflammation. In this perspective, we highlight food-derived bioactives that have a potential application in the prevention of obesity-exacerbated IBD, targeting energy metabolism, M1 (classical activated)-M2 (alternatively activated) macrophage polarization, and gut microbiota. ? 2018 American Chemical Society.
Subjects
ATM; bioactives; gut microbiota; IBD; obesity
Other Subjects
Automatic teller machines; Macrophages; Metabolism; Pathology; Bioactives; Dietary components; Energy metabolism; Gut microbiota; Inflammatory bowel disease; Intestinal inflammation; Microbial composition; obesity; Nutrition; phytochemical; adipose tissue; complication; diet; drug effects; energy metabolism; human; inflammatory bowel disease; intestine flora; macrophage; macrophage activation; microbiology; obesity; pathophysiology; physiology; Adipose Tissue; Adiposity; Diet; Energy Metabolism; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases; Macrophage Activation; Macrophages; Obesity; Phytochemicals
Type
journal article