GENETIC VARIANTS OF MYELOPEROXIDASE AND CATECHOL-O-METHYLTRANSFERASE AND BREAST CANCER RISK
Resource
EUROPEAN JOURNAL OF CANCER PREVENTION v.14 n.3 pp.257-261
Journal
EUROPEAN JOURNAL OF CANCER PREVENTION
Journal Volume
v.14
Journal Issue
n.3
Pages
257-261
Date Issued
2005
Date
2005
Author(s)
Lin, S-C
Chou, Y-C
Wu, M-H
Wu, C-C
Lin, W-Y
Yu, C-P
Yu, J-C
You, S-L
Chen, C-J
Sun, C-A
Abstract
This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O- methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.(C) 2005 Lippincott Williams & Wilkins, Inc.
Subjects
breast cancer
catechol-O-methyltransferase
polymorphisms
myeloperoxidase
oestrogen exposure
SDGs
Type
journal article